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Replacement of DMF with DMSO, dioxane or dimethylacetamide (DMA) has been reported to avoid the formation of this by-product during the linker attachment step 69,72

Increased FFAs can lead to hepatic lipotoxicity, generation of reactive oxygen, and damage to the mitochondrial membrane (52)

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regarding this, the movements to remove need to be faster to release that sensation

A possible answer to this question could derive from clinical trials aiming at assessing the effect of drugs used for IR treatment on kidney function

doi: 10.1007/s12017-009-8091-0