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They determined that while studies involving animals and cell cultures, along with small human studies, suggested the peptide held potential to promote healing, "human data are extremely limited," and "rigorous, large-scale trials are lacking." The data are even more limited on TB-500

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We were exploring ways of developing peptides that bind selectively, and we were very successful at that, but then we confronted the problem that our short, 23-residue peptides are not promising therapeutic candidates primarily because they cannot get into cells, Keating says