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The catalytic core of complex IV is composed of the mitochondrial genome (mtDNA) encoded proteins MT-CO1 and MT-CO2 as well as cytochrome a and cytochrome a 3

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335 Quercetin, which targets the Bcl-2 family member hypoxia-inducible factor-1 (HIF-1) and the antiapoptotic PI3K/AKT and p21 signaling pathways, has demonstrated synergistic effects (Table 1)

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The main indications for BT prescriptions are summarized in the following Table: Based on the experience of the included physicians, patients reported diverse outcomes: no effect (1.4%), a sense of well-being without symptom improvement (15.1%), partial symptom improvement (58.9%), and a spectacular improvement in symptoms (24.7%)

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