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Moreover, direct administration of cysteine to increase GSH is not a viable option, because of its poor absorption and toxicity at high doses (Johnson et al., 2012)

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showed that coincubation with S

May reduce inflammation and fibrosis indirectly via thymosin pathways observed in animal models [11]

Given the importance of glucose and glutamine metabolism in pancreatic cancer cells, it is not surprising that gemcitabine resistance is closely associated with metabolic status, including cellular glucose and glutamine levels
