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Generation of DNA-damaging reactive oxygen species via the autoxidation of hydrogen sulfide under physiologically relevant conditions: chemistry relevant to both the genotoxic and cell signaling properties of H(2)S

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GSNOR/denitrosylation tuning seeks to rebalance reversible S-nitrosationa bona fide signalling modificationwithout collapsing NO pathways, using context-specific modulation of GSNOR and denitrosylating systems (thioredoxin/-glutamyl transpeptidase axes) so that excessive, persistent S-nitrosation is relieved while physiological, transient nitrosation on target cysteines is preserved (Chatterji and Sengupta 2021

The researchers reported that the BPC-157 murine models appeared to exhibit higher numbers of collagen, reticulin, and blood vessel development than the ones in the control group
