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However, these drugs can target cysteines in multiple proteins: for example, sulphoraphane targets NF-B (49) as well as both JUN and FOS of the AP1 complex (50), and proteomic and other analyses have shown that synthetic oleanane triterpenoids target a range of proteins containing reactive cysteines (51)
[DOI] [PMC free article] [PubMed] [Google Scholar] 99.Wilcken B
GSH maintains protein thiols in the reduced state and serves as a storage form of cysteine
Olsson EM, von Schele B, Panossian AG
Currently, it is a treatment option for NSCLC patients who have METEx14 mutations
EBioMedicine 53 , 102696 (2020)
