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In addition, B12 deficiency can result in Megaloblastic Anemia, a type of anemia in which the red blood cells grow without dividing, becoming enlarged
371 Elevated BBB permeability of the system was observed due to a combination of lactoferrin-mediated BBB transcytosis and photothermal effects

doi:10.1371/journal.pone.0217223
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This more fundamental approach may help maintain metabolic health over time but does not produce the acute appetite suppression and weight loss effects of receptor agonists