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Nevertheless, macrometastatic outgrowth remains a highly inefficient process, in part because of the plethora of environmental noxae that kill unadapted tumor cells after intravasation [21]

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Petrie, the general's medical adviser, was opposed to amputation, but it was done

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In fact, for many years the general axiom was that most melanomas develop de novo and that only a minority originated from a nevus.34,35 This axiom requires some clarification, since the most common melanoma in our setting, lentigo maligna melanoma, arises from a series of previous mutations in situ (even if they are not nevic), such as lentigo maligna or similar entities