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Description

After three months of intragastric Dihexa administration (1.44 or 2.88 mg/kg), the APP/PS1 mice showed restored Morris water maze performance, increased neuronal cell counts and synaptophysin expression on Nissl staining, reduced microglial and astrocyte activation, decreased pro-inflammatory cytokines (IL-1, TNF-) and increased anti-inflammatory IL-10

Purity and structure were verified by LC-MS

The derivatization procedure was performed as follows: 30 L of 4 mol/L NaBH 4 , 20 L of 2 mmol/L EDTA/DTT, 10 L of 1-octanol and 20 L of 1.8 mol/L HCl were placed in the derivatization vial containing 30 L of sample

(131) demonstrated the presence of iron-laden macrophages and elevated ferritin expression in lung tissue from IPF patients (131)

The present study also showed a decrease in glutathione content and enzymatic activity of antioxidants, such as SOD, GSH-Px, CAT, and GSH-R, in renal tissue of CdCl 2 -injected mice