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Prolonged use of Vitamin B6 (over 2 months) at high doses exceeding 1g/day can lead to severe peripheral neuropathy, with symptoms including unsteady gait and numbness in the hands and feet

10.1016/j.etap.2016.01.008 [DOI] [PubMed] [Google Scholar] 43.Qi Z, Chen X, Guo W, Fu C, Pan S

Phase 1: Introduction (weeks 1 to 4) Start below your expected long-term concentration

D.d'AvignonA.et al (2021)

Inclusion criteria included full-text publications in English

Although promotion of angiogenesis and cell proliferation could entail benefits in the short-term in terms of tissue healing, this could be a double-edged sword, as these same processes are how many cancers initiate and spread