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This is largely due to the livers first-pass metabolism, which converts THC into an active metabolite, 11-hydroxy-THC (Chayasirisobhon, 2021), which can reach concentrations three times higher through inhalation (Schwilke et al., 2009)

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doi: 10.3389/fnins.2025.1614297 Received 09 May 2025 Accepted 16 June 2025 Published 26 June 2025 Volume 19 - 2025 Edited by Katarzyna Stachowicz, Polish Academy of Sciences, Poland Reviewed by Antonio Gambardella, University of Magna Graecia, Italy Qinrui Li, Peking University Peoples Hospital, China Updates Copyright 2025 Shi, Yang, He, Wang, Zheng, Wang, Hao, Feng, Ma, Zhang and Liu

Oxalate nephropathy and the mechanism of oxalate-induced kidney injury