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This review provides a comprehensive overview of the latest findings on the involvement and signaling mechanisms of ferroptosis in PF pathogenesis, emphasizing potential novel anti-fibrotic therapeutic approaches targeting ferroptosis for PF management

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[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Yeung Y.W.S., Ma Y., Deng Y., Khoo B.L., Chua S.L

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In essence, LL-37 converts normally non-immunogenic self-DNA into a powerful trigger for autoimmune activation

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Nrf2, nuclear factor erythroid 2-related factor 2

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doi:10.1016/S0022-3565(24)39314-0

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Given the coupling between copper and energy status (e.g copper is a cofactor at Complex IV of the ETC) and how intensely metabolically active neurons are, it seems like short-term IP GHK-cu in the brain is acting analogously to the copper ionophore elesclomol in Tregs

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