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This occurs during acute infection or if the immune system is suppressed, for example, when the person also has HIV infection

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doi:10.1001/archotol.1993.01880180068013

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At this point, DAG is generated

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-Toxin desensitizes neutrophils to G-CSF by reducing its receptor levels Because -toxin has no inhibitory effect on the production of G-CSF in vivo and in vitro, we supposed that -toxin directly affected neutrophils and blocked their differentiation

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