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Braces, wraps, or cushioned footwear can relieve pressure
Local anesthetics: Review of pharmacological considerations
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10.1056/NEJMoa1709449 [DOI] [PMC free article] [PubMed] [Google Scholar] Niranjan, R
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In section 2.9 of the ICH S7A, conditions under which studies may not be necessary (e.g., locally applied products) and considerations for biologics are described
