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At eight weeks post-treatment, 44% of HER2 3+ patients achieved stable disease, accompanied by increased CD8 + T cell infiltration in tumors, suggesting adaptive immune activation via antigen presentation (275)

In cases of long-standing or severe deficiency, nerve damage may be partially irreversible, highlighting the importance of early detection and treatment

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Due to activation of the mTOR pathway, which regulates cell growth [18], and modulation of the ATF6 pathway, affecting cytoskeletal structure [19], senescent cells often take on an enlarged and irregular morphology [18, 19]

N Engl J Med (2002) 347:20209