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The most studied mechanisms include: upregulation of growth hormone receptors in fibroblasts (increasing sensitivity to healing signals), activation of the FAK-paxillin pathway (promoting cell adhesion and migration), modulation of the nitric oxide system through Src-Caveolin-1-eNOS phosphorylation (enhancing vascular function), and dual activation of the Egr-1/NAB2 gene loop (promoting organized, non-chaotic blood vessel growth)

doi: 10.1016/j.cmet.2023.06.010

Cytokine regulation of tight junctions

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have demonstrated that HIF-1 promotes bone resorption mediated by osteoclasts (OCs), while angiopoietin-like 4 (ANGPTL4) compensates for HIF-1s inadequate stimulation of OC activity and promotes the proliferation and differentiation of osteoblasts (OBs) (138)

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