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It stands to reason then, that glutathionylation of SOD1 alters the K D of a multitude of individual variants in a unique, allosteric-like fashion and that it is the combination of K D ( u SOD1) and K D ( gs SOD1) (Fig

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There is widespread acknowledgement that stress can lead to both physiological and anatomical alterations within the brain, and stress has been linked to the development of several neuropsychiatric conditions such as anxiety, depression, and insomnia (42)

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To explore impairments in autophagy with age, after measuring GTP levels in neurons from mice across the age span, cells were fixed and immunostained for GTPases Rab7, a marker of late endosomes [36], and Arl8b, a lysosomal protein [37]

[138] new UK prescriptions were not issued during the shortage