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10.13075/mp.5893.00137 18 D'SouzaL

Inflammation Modulation: Supporting a balanced inflammatory response and overall wellness

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Abbreviations 2HG: 2 -Hydroxyglutarate (also known as 2-oxoglutarate) ALL: Acute lymphoblastic leukemia Arg: Arginine AS: Asparagine synthetase Asn: Asparagine ASNase: Asparaginase BCAT1: Branched-chain amino acid transaminase 1 Cys: Cysteine EGFR: Epidermal growth factor receptor G-CIMP: Glioma-CpG island methylator phenotype GBM: Glioblastoma multiforme GDH: Glutamate dehydrogenase GLA: Glutaminase Gln: Glutamine GLS: Gls gene Glu: Glutamate GSH: (reduced) Glutathione GSSG: (oxidized) glutathione IDH1: Isocitrate dehydrogenase 1 IDH2: Isocitrate dehydrogenase 2 JHDMs: Jumonji-C-domain-containing histone demethylases Met: Methionine MRS: Magnetic resonance spectroscopy mTOR: Mechanistic target of rapamycin (or mammalian target of rapamycin) mTORC1: mTOR complex 1 mTORC2: mTOR complex 2 PDH: Pyruvate dehydrogenase PPP: Pentose phosphate pathway ROS: Reactive oxygen species siRNA: Small interfering RNA TCA: Tricarboxylic acid TET: Ten-eleven-translocation wt: Wild-type KG: -Ketoglutarate References Albrecht J, Norenberg MD (2006) Glutamine: a trojan horse in ammonia neurotoxicity