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We and others have demonstrated that dopaminergic cell death associated with PD-risk factors (genes and environmental exposures) is mediated by a dysfunction in both bioenergetics and redox homeostasis coupled to alterations in central carbon metabolism

doi: 10.1016/j.cgh.2019.07.045 3 Van CutsemESagaertXTopalBHaustermansKPrenenH

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Its important to note that while ketamine is not FDA-approved for the treatment of mental health disorders like treatment-resistant depression, ongoing research and randomized controlled trials are exploring its potential in this area

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The enzyme GGT and hydrogen sulfide (H2S) speed up cell damage, harming organs and tissues