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Oral contraceptives can decrease the action of Mecobalamin by reducing its concentration in the body

An ice pack applied prior to injection also helps to dull the sensation and ease discomfort
While results vary from person to person, many people notice benefits when injections are used appropriately

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"Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study"