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The method applied in the in-vitro enzyme assay is detailed in supplementary material

Rao M, Nassiri V, Alhambra C, Snoeys J, Van Goethem F, Irrechukwu O, Aleo MD, Geys H, Mitra K, Will Y (2023) AI/ML models to predict the severity of drug-induced liver injury for small molecules

While they are frequently stacked together, they operate through distinct molecular pathways

Cellular Health Peptides are able to trigger repair pathways and increase mitochondrial function in testicular and epididymal tissue cells, slowing cellular aging

The difference between the effects of both QIs on the cell viability ( Figure 2 ) and caspase 3 activation ( Figure 4 ) suggests that upon GSH depletion, the decrease in cell viability is not only apoptosis dependent but also most likely depends other cell death pathways, such as necrosis ( IC 50 values of QIs under GSH-depleted conditions were around 20 M ( Figure 2 ), which is higher than the plasma concentrations of AQ and DEAQ found in patients, normally in nanomolar to micromolar ranges (Laurent et al., 1993