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I have had a similar reaction that has persisted for 3 months

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The adenosine binding pocket is strikingly similar, with the ribose moiety stacking with the conserved Trp61 residue and forming a network of polar interactions linking across the dimer interface via the conserved Glu71-His72 motif (Figs

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In the opinion of these authors, the possibility of resuming and continuing cobalamin therapy by desensitized patients confirmed that desensitization was effective and the intended therapeutic effect was achieved [9,10,11,12,13,14,15,16]