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see also Section 2.8), following the datasheet recommendations

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Inflammatory Bowel Disease Inflammatory bowel disease (IBD) includes two chronic intestinal inflammatory conditions: Crohn's disease (CD) and ulcerative colitis (UC), characterized by an overactivation and dysregulation of the immune system with a relapsing-remitting pattern

You had mentioned that trazodone didnt work for you and that you were using something with Valerian root in it

doi: 10.1016/j.stress.2025.101102