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With our increasing understanding of the impact of gut microbiota on human health, the gut microbiome has emerged as a novel target for treatment

Mechanistically, we found that KCNN3-mediated ion channel activation can promote the phosphorylation of CTCF, thereby inducing the transcription of the EMT-related factor SATB1, enhancing the HCC progression in vitro and in vivo

This research was funded in part through the NIH/NCI Cancer Center Support Grant P30CA013696 and utilized the Molecular Pathology Shared Resource for all tissue processing and immunohistochemical staining as well as its Tissue Bank for providing COVID-19 and control lung samples

Ajoolabady et al., 2025)

Nat Rev Neurol 15(10):565581 Ben-Azu B, Del Re EC, VanderZwaag J, Carrier M, Keshavan M, Khakpour M, Tremblay M (2023) Emerging epigenetic dynamics in gut-microglia brain axis: experimental and clinical implications for accelerated brain aging in schizophrenia

doi: 10.1007/s00709-022-01794-7
