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(1969) Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions

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Biochem Biophys Res Commun (2017) 482:41925

therefore, potentially inflammatory conditions associated with cancer development.37 In another experimental study, high doses of potassium sorbate led to chromosomal aberrations in human blood lymphocytes.38 Potassium metabisulfite showed no carcinogenicity in mice models39 but enhanced gastric carcinogenicity in one rat study.40 We previously discussed the mechanistic plausibility of nitrites and nitrates.12 Briefly, hypotheses rely on the stepwise conversion of nitrate into nitrite in the body, followed by the formation of N -nitroso compounds, which according to the International Agency for Research on Cancer are probably carcinogenic to humans.6 Mechanistic studies suggest that the presence of nitrosatable compounds found in meat accelerate the formation of these N -nitroso compounds, whereas vitamin C and other antioxidants often found in fruit and vegetables inhibit it.641 In our models, associations between nitrites and nitrates and cancer incidences persisted after adjustment for intakes of haem iron, polyunsaturated fatty acids, and vitamins C and E

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