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The frequencies were obtained from pooled data of clinical trials involving either adults receiving clomipramine hydrochloride (N=322) or placebo (N=319) or children treated with clomipramine hydrochloride (N=46) or placebo (N=44)

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We recognize the critical need for future studies to validate these using human-derived cell lines and PDX models to confirm the translational significance of our results, and are developing and testing strategies for utilizing immunodeficient mice for studies of obesity and cancer [40]