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In breast cancer cell lines, SAMe treatment modulates the expression of miRNA-34a, miRNA-34c and miRNA-486-5p leading to caspase-dependent apoptosis and autophagy [251], but is also able to epigenetically regulate uPA and MMP-2 genes by hypermethylation of CpG promoter sequences inhibiting cellular invasion and growth [147,252,253]

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Hedtke B, Alawady A, Albacete A, Kobayashi K, Melzer M, Roitsch T et al (2012) Deficiency in riboflavin biosynthesis affects tetrapyrrole biosynthesis in etiolated Arabidopsis tissue

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Insights into ferroptosis: Targeting glycolysis to treat graves' orbitopathy
