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[DOI] [PMC free article] [PubMed] [Google Scholar] Sharma SS, Dietz KJ

Although a higher lipophilicity should lead to an enhanced cellular uptake, as Pt(IV) complexes (unlike Pt(II) complexes) enter cells solely by passive diffusion, a lack of correlation between log P values and cellular Pt levels is not unprecedented 31,32

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Interestingly, TG2-mediated GST polyamination had no effect on its GSH binding affinity or its GST enzymatic activity

MRP (human multidrug resistance protein), a member of the superfamily of ATP-binding cassette membrane transporters, can confer resistance to multiple classes of chemotherapeutic agents (Kuo et al., 1998