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191 Our research group has identified two E3 ubiquitin ligases which indirectly regulate Ctr1A, the Drosophila orthologue of CTR1: supernumerary limbs (Slmb) and von HippelLindau (VHL) protein

Despite the importance of cSVD, we have no effective proven treatments other than risk factor modification

Sofroniew, 2009), which are closely related to glial scar formation

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This would render oral formulations of DSIP virtually ineffective compared to nasal spray and injections [5]