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Some neurons appear to be both cholinergic and nitrergic, and there is a population of cells that do not express the rate-limiting enzymes for the production of either ACh (cholineacetyltransferase, ChAT) or nitric oxide (nitric oxide synthase, NOS)

PMC 1133600

LCMS/MS for global proteome, phosphoproteome, acetylproteome and glycoproteome Global, phosphorylated and acetylated proteome fractions were separated on in-house packed C18 columns (25 cm, 1.9 m

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Zhang, 2023)

However, these results are usually limited to skin health improvements, such as reduced pigmentation and increased brightness, rather than systemic effects