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NAC restores mGluR3 receptor activity through glutamate carboxypeptidase II (GCPII) inhibition, favouring the antioxidant response through Nrf-2 and Nf-B pathways [139]

doi: 10.2460/ajvr.73.7.1002

After 4 weeks of the drug administration, in comparison with the abundance of Firmicutes, Bacteroidetes, and Actinobacteria of the model group, the abundance of Firmicutes of drug-treated groups is lower ( p = 0.847 for the high-QLZDD-dose group and p = 0.841 for the haloperidol group), and the abundance of Bacteroidetes ( p = 0.004 for the high-QLZDD-dose group and p = 0.067 for the haloperidol group) and Actinobacteria ( p = 0.006 for the high-QLZDD-dose group and p = 0.001 for the haloperidol group) of drug-treated groups is higher (Figure 7C)