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The role of zonulin in T1D was further reinforced by Watts and colleagues who demonstrated that T1D-associated symptoms could be alleviated in disease-prone rodent models following administration of a zonulin inhibitor (Watts et al

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A particular point is a very safe profile (LD1 could be not achieved) [7,16], a point recently confirmed in a large study of the Xu and collaborators [83]

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