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(11) reported the first randomized, prospective and controlled clinical trial for treatment-intractable childhood epilepsy in which 3 month administration of a KD resulted in significant reduction in seizure frequency

3 Mammalian CHAC2: defining its role in glutathione homeostasis, cancer progression and stem cell fate In addition to CHAC1, which is found exclusively in higher eukaryotes, organisms from bacteria to mammals possess a CHAC2 enzyme that exhibits a highly similar glutathione-specific GCT activity ( However, more recent research has revealed that CHAC2 expression is subject to complex regulation and is implicated in diverse cellular processes

ESRD, end-stage kidney disease

This function is vital for cell survival under conditions of proteotoxic stress

Nfe2l2 -deficient mice are hypersensitive to septic shock [120], display more severe lung inflammation induced by cigarette smoke [121], are highly susceptible in different liver inflammation models [122]