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Rather than work separately, they engage in a crosstalk, which involves interaction of different cellular pathways

The dual role of Nrf2 in nonalcoholic fatty liver disease: Regulation of antioxidant defenses and hepatic lipid metabolism

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By selectively inhibiting NNMT , 5-Amino-1MQ can reduce the methylation of nicotinamide, leading to increased intracellular NAD availability and enhanced metabolic activity
