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In addition to their cytotoxic effects, many small-molecule agents exhibit insufficient penetration into critical sanctuary sites, including granulomas, the blood-brain barrier (BBB), and various intracellular compartments, where pathogens can persist and facilitate relapse (Pardridge, 2020

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Tocilizumab and baricitinib for recovery from acute exacerbation of combined pulmonary fibrosis and emphysema secondary to COVID-19 infection: a case report

Diabetes Obes Metab 13(3):243250

A large neuroimmunology literature consistently concludes that cytokines do not have to be detectable in the periphery in order to have an effect on sickness-related symptoms

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