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10.1016/j.jenvman.2011.06.029 J

Protective effects of naringenin from citrus sinensis (var

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However, excessive oxidative stress may lead to irreparable protein oxidation, such as backbone breakage, protein carbonylation, and covalent crosslinking between tyrosine residues [103]

Maldonado J, Gil-Campos M, Maldonado-Lobon JA, Benavides MR, Flores-Rojas K, Jaldo R, Jimenez Del Barco I, Bolivar V, Valero AD, Prados E, Penalver I, Olivares M (2019) Evaluation of the safety, tolerance and efficacy of 1-year consumption of infant formula supplemented with Lactobacillus fermentum CECT5716 Lc40 or bifidobacterium breve CECT7263: a randomized controlled trial

It has been used medicinally for over two millennia the Greek physician Dioscorides first documented its healing properties around 4090 AD for treating liver ailments, and by the 16th century European herbalists like John Gerard had noted its use for liver support and digestive issues [1][3]