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Selenides and selenium sulphides occur mainly in acidic, oil-rich soils with a high content of organic matter

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Jiang L., Kon N., Li T., Wang S.-J., Su T., Hibshoosh H., Baer R., Gu W

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A 2015 study by Huang and colleagues in Drug Design, Development and Therapy used a rat alkali-burn model (n=10 per group) and HUVECs treated with BPC-157 at 200800 ng/mL, reporting accelerated wound closure with enhanced granulation tissue, reepithelialization, and dermal remodeling by day 18, alongside increased endothelial migration and vascular tube formation in vitro via ERK1/2 phosphorylation though the abstract does not report numeric % wound closure or p-values

Even though variable GSH concentrations were not tested, the authors suggested that Lys19 replacements have a negative effect on the reactivity of the glutathionylated enzyme with the reducing agent