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Keywords: glutathione peroxidase 1, oxidative stress, selenium, selenocysteine, endothelial dysfunction, cardiac protection, angiogenesis, inflammation, atherosclerosis, stroke, neurodegeneration, cancer Graphical Abstract Glutathione peroxidase 1 (GPx1) is a member of a family of antioxidant enzymes that reduce hydrogen peroxide and soluble lipid hydroperoxides using glutathione (GSH) as a source of reducing equivalents 1

Humanized preclinical models of BDNF regulation and genetic variability, such as iPSC-derived neurons and brain organoids support the evaluation of BDNF regulation in a patient-specific manner, aligned with efforts developing personalized interventions [328]

However, in both animals, HEV viremia and fecal shedding of virus were observed indicating that infection had occurred (Table 6)

Additionally, NAD+ may help regulate circadian rhythms, enhancing sleep quality and mental clarity

In fact, it has been reported that GPX4 expression in the early secretory phase is markedly lower in the eutopic endometrium of women with endometriosis compared with those with normal endometrium (63)