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Among the various regulatory factors, peroxisome proliferator-activated receptor (PPAR) coactivator 1 (PCG-1), the master regulator of mitochondrial biogenesis, emerges as an important component involved in the defective mitochondrial biogenesis in CKD (Sharma et al., 2013

On the other hand, astrocyte depletion in the chronic phase of MS resulted in disease attenuation and reduced inflammatory infiltrate (107)

Shelterin is a dimeric complex with extensive structural heterogeneity

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To address this point, it was explored whether APOE treatment of neurons affected the catalytic activity of enzymes that have previously been implicated in tau phosphorylation, such as glycogen synthase kinase 3beta (GSK3), P35, and cyclin-dependent protein kinase 5 (CDK5)

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