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Key substrates include transcription factors such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), tumor protein 53 (p53), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), and nuclear factor erythroid 2-related factor 2 (Nrf2), which play integral roles in maintaining cellular homeostasis (Mohammed et al., 2021)

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Mr Strangis said Melanotan II use was common in the fitness industry but two friends who had been injecting themselves had not reported any problems