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Research indicates that the reduction in serum B12 levels typically becomes clinically significant after several years of continuous metformin therapy
Most patients see initial improvements within 3-4 weeks , with continued progress over months
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[DOI] [PubMed] [Google Scholar] 15.Patel DS, Veverka KA, Hansen JB, Yamauchi PS, Alonso-Llamazares J, Lebwohl M
