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2017;96:e7029

doi: 10.1007/s10637-011-9775-5 65 MaDJGalanisEAndersonSKSchiffDKaufmannTJPellerPJet al

Brain ischemia or stroke are the best examples of these disorders, as they are associated with intracellular ATP depletion [220,241,242], as well as hepatic encephalopathy, in which intracellular Na + concentration in astrocytes is markedly raised as a result of NH 3 /NH 4 + toxicity [243]

Following activation and execution of their effector functions, the majority of effector CD4+ T cells undergo programmed cell death (apoptosis), making them unsuitable for long-term immunity (136, 137)

CYP1, CYP2, CYP3, CYP4 and CYP7 are believed to play crucial roles in hepatic as well as extra-hepatic metabolism and elimination of xenobiotics [50], [58], [84]

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