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Analogue-based Drug Discovery

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High-dose IV Vitamin C is a natural complement: it supports the body's antioxidant defenses during treatment, helps healthy cells withstand oxidative damage, and supports recovery between sessions

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This treatment gap, particularly in people with obesity and insulin resistance, could be at least partially overcome with GLP-1 and GIP/GLP-1 receptor agonists, as this clinical setting calls for weight loss (indirect anti-inflammatory action) and a potential direct anti-inflammatory action of these medications to reduce asthma exacerbations, possibly through some of the described mechanisms

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Hiplito I, Mago J, Rosas FE, Carhart-Harris R

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In addition to normal tissues, it has been reported that GPx2 is upregulated in a variety of tumor cells [76, 95] and is associated with tumor cell proliferation and poor prognosis of patients [96, 97]

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166 MiR-126 also downregulates the target gene Sprouty-related protein 1 (SPRED1) which then activates the Raf-1/ERK1/2 signaling contributing to angiogenesis

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