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Description
Analogue-based Drug Discovery

High-dose IV Vitamin C is a natural complement: it supports the body's antioxidant defenses during treatment, helps healthy cells withstand oxidative damage, and supports recovery between sessions

This treatment gap, particularly in people with obesity and insulin resistance, could be at least partially overcome with GLP-1 and GIP/GLP-1 receptor agonists, as this clinical setting calls for weight loss (indirect anti-inflammatory action) and a potential direct anti-inflammatory action of these medications to reduce asthma exacerbations, possibly through some of the described mechanisms

Hiplito I, Mago J, Rosas FE, Carhart-Harris R

In addition to normal tissues, it has been reported that GPx2 is upregulated in a variety of tumor cells [76, 95] and is associated with tumor cell proliferation and poor prognosis of patients [96, 97]

166 MiR-126 also downregulates the target gene Sprouty-related protein 1 (SPRED1) which then activates the Raf-1/ERK1/2 signaling contributing to angiogenesis
