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Long-term levodopa treatment, while effective in alleviating motor symptoms, has been associated with increased oxidative stress and the generation of toxic metabolites, which can accelerate the loss of dopaminergic neurons

Patent Number: 7,163,925

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J Biol Chem (2013) 288:1092335

It acts primarily through gene expression modulation, delivering copper to enzymes and triggering transcription factor cascades rather than saturating one receptor