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After metabolic pathway analysis, it was found that the antidepressant mechanism of ZZCD on CUMS rats related to the improvement of brain metabolism in Phenylalanine, tyrosine and tryptophan biosynthesis, Glutathione metabolism, Phenylalanine metabolism, Lysine degradation, Cysteine, and methionine metabolism, Tyrosine metabolism, and Tryptophan metabolism

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Melatonin supplementation alone, though, wasnt enough to return the AD mice to normal control levels, but the improvements were significant.[ref][ref][ref][ref] Another study using a mouse model of AD found that melatonin reduced the signs of Alzheimers, including cognitive deficits

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Relationship between manganese superoxide dismutase (MnSODAla-9Val) and glutathione peroxidase (GPx1 Pro 197 Leu) gene polymorphisms and alopecia areata