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Role of cysteine cathepsins in matrix degradation and cell signalling

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Brukinsa, in combination with Genentechs Gazyva, is now authorized for the third-line treatment of relapsed or refractory follicular lymphoma (FL)

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Lectin pathway mediates complement activation by SARS-CoV-2 proteins

However, in a subsequent 24-week trial involving 536 obese participants, AOD 9604 did not achieve statistically robust, clinically meaningful weight-loss outcomes versus placebo, and the obesity-drug development program was discontinued around 2007