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doi: 10.4103/0973-7847.70921

Since cytokines can also regulate the activity of tryptophan catabolism in astrocytes and microglia, this finding corresponds to the alterations in the kynurenine pathway observed in the brains of individuals with schizophrenia (186)

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The interaction between IL-18 and the kynurenine pathway, which is involved in tryptophan metabolism, may also contribute to serotonin deficiency, a feature of depression [110]

This explains its documented ability to heal transected tendons, detached ligaments, and even crushed nervesoutcomes that typically require long recovery periods or surgical repair

rFVIII=recombinant Factor VIII