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Methylation anomalies, either hypomethylation or hypermethylation depending upon the target (genes or their promoters), may lead to testicular cancer, initiated from the period of gonadal development

119 On the contrary, cardiac-specific caPI3K expression was protective against pathological cardiac hypertrophy

Song WY, Park J, Mendoza-Czatl DG, Suter-Grotemeyer M, Shim D, Hrtensteiner S, et al

Developing cell-type-specific SIRT1 regulatorsfor example, hepatocyte-targeted molecules using GalNAc ligands or KC-specific nanoparticlesmay allow targeted activation, while selective inhibition in cells such as activated HSCs could also be explored

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AM J Case Rep 2014