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This finding was corroborated by a 3T Magnetic Resonance Spectroscopic Imaging (MRSI) study, assessing multiple regions in the brain [13]

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discussion 153-134

Upon administration of LPS, luteolin pretreatment prevents these inflammatory processes from developing (100)

The mechanism underlying this therapeutic effect could be related to stimulation of the Cl - /butyrate exchanger activity, to reduction of mistrafficking or misfolding of the SLC26A3 protein, or alternatively butyrate may induce the expression of SLC26A3 gene, which contains a 290-bp region between residues -398 and -688 that is crucial for high-level transcriptional activation induced by butyrate

When a chelating agent is used to remove a toxic metal ion from a sensitive biological molecule, its chemical affinity for that metal ion (toxicant) should be greater than that of the metal towards the sensitive biological molecule