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Therefore, these mechanisms and therapeutic benefits require further validation in large-scale, controlled human trials

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In addition, many available studies rely on relatively small cohorts or cross-sectional designs, limiting the ability to establish causal relationships between gut dysbiosis and PCOS development (61, 72)

Abstract The STEP 5 trial assessed the efficacy and safety of once-weekly subcutaneous semaglutide 2.4 mg versus placebo (both plus behavioral intervention) for long-term treatment of adults with obesity, or overweight with at least one weight-related comorbidity, without diabetes